Adaptive Oncogenesis : : A New Understanding of How Cancer Evolves inside Us /

Adaptive Oncogenesis : : A New Understanding of How Cancer Evolves inside Us / / James DeGregori DeGregori.

Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer’s occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem...

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Bibliographic Details
Superior document:Title is part of eBook package: De Gruyter Harvard University Press Complete eBook-Package 2018
VerfasserIn:
DeGregori, James DeGregori,
Place / Publishing House:Cambridge, MA : : Harvard University Press, , [2018]
©2018
Year of Publication:2018
Language:English
Online Access:
Physical Description:1 online resource (250 p.) :; 16 line illustrations
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Table of Contents:
  • Frontmatter
  • Contents
  • Foreword
  • Introduction
  • The Evolution of Life Spans and Disease Avoidance
  • Understanding Evolution at Organismal and Somatic Levels
  • The Evolution of Multicellularity and Tumor Suppression
  • Mechanisms of Tumor Suppression
  • Dominant Views of the Mechanisms of Oncogenesis
  • Adaptive Oncogenesis
  • Limiting Somatic Evolution in Youth
  • Changing Adaptive Landscapes with Aging
  • Changing Adaptive Landscapes with Carcinogenic Exposures
  • Tissue Architecture and Tumor Suppression
  • Peto’s Paradox
  • Prolonging Tissue Maintenance to Delay Aging and Cancer
  • Understanding Clinical Data from an Evolutionary Perspective
  • The Causes of Cancer in Early Childhood
  • Evolution-Informed Strategies to Combat Cancer
  • A New Framework for Understanding and Controlling Cancer
  • References
  • Acknowledgments
  • Index

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