Living Without Oxygen : : Closed and Open Systems in Hypoxia Tolerance / / Peter W. Hochachka.

• Superior document: Title is part of eBook package: De Gruyter HUP e-dition: Complete eBook Package
• VerfasserIn: Hochachka, Peter W.,
• Place / Publishing House: Cambridge, MA : : Harvard University Press, , [2013]; ©1980
• Year of Publication: 2013
• Edition: Reprint 2014
• Language: English
• Physical Description: 1 online resource (181 p.)

Innumerable clinical problems have as their basis some derangement in oxygen-dependent metabolism. To explore mechanisms of adjusting to oxygen limitation, Living without Oxygen presents a bestiary of exotic anaerobes that illuminate elements of metabolic biochemistry only dimly seen in studies using standard experimental animals. With their exaggerated anaerobic capabilities, Hochachka's diving mammals, airbreathing fishes, and hypoxia-adapted lower vertebrates allow a detailed assessment of what can and what cannot be adjusted in the process of extending hypoxia tolerance. The book places the enzymatic and biochemical machinery firmly in the biological context and assumes only a modest familiarity with bioenergetics and metabolic biochemistry. The author's clear prose should make this technical presentation pleasantly unintimidating for any physiologist, biochemist, or clinical investigator. The insights of his unique approach make Living without Oxygen essential reading.

Table of Contents

Frontmatter -- Preface -- Contents -- Chapter One. Anaerobic Metabolism: What Can and What Cannot Change -- Chapter Two. Helminths and the Usefulness of Carbon Dioxide -- Chapter Three. Coupled Glucose and Amino Acid Catabolism in Bivalve Molluscs -- Chapter Four. Coupled Glucose and Arginine Metabolism in Cephalopods -- Chapter Five. Key Elements of Anaerobic Glycolysis -- Chapter Six. Integrating Aerobic and Anaerobic Glycolysis -- Chapter Seven. Integrative Mechanisms in Hypoxia-Adapted Fish -- Chapter Eight. Air–Breathing Fish -- Chapter Nine. Diving Marine Mammals -- Epilogue -- Index