Muscle aging : inclusion-body myositis and myopathies / / edited by Valerie Askanas and w. King Engel.

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Year of Publication:2012
Language:English
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Physical Description:xii, 250 p., [8] p. of plates :; ill. (some col.)
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Table of Contents:
  • Ageing of the human neuromuscular system : pathological aspects / W. King Engel and Valerie Askanas
  • Aging of the human neuromuscular system : clinical considerations / W. King Engel and Valerie Askanas
  • Aging of the human neuromuscular system : patient vignettes / W. King Engel, Shalini Mahajan, Valerie Askanas
  • Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences / Salvatore DiMauro, Eric Schon, Michio Hirano
  • Protein degradation in ageing cells and mitochondria : relevance to the neuromuscular system / Jenny Ngo and Kelvin Davies
  • Human muscle protein metabolism in relation to exercise and aging : potential therapeutic applications / Micah J. Drummond, Blake B. Rasmussen
  • Pathogenesis of sporadic inclusion-body myositis / Valerie Askanas, W. King Engel, Anna Nogalska
  • Inflammatory and autoimmune features of inclusion-body myositis / Marinos Dalakas
  • Clinical symptoms, physical findings, and diagnostic investigations / Frank Mastaglia
  • Pathologic diagnostic criteria of s-IBM and h-IBMS muscle biopsies / Valerie Askanas and W. King Engel
  • Function and mutations of the GNE gene leading to DMRV/h-IBM, animal models, and potential treatments / May Malicdan, Satoru Noguchi, Ichizo Nishino
  • Clinical and ethnic spectrum, laboratory data, and epidemiology of h-IBM due to GNE mutations / Zohar Argov, Ishizo Nishino, Ikiyo Nonaka
  • Consequences of the h-IBM characteristic GNE mutations on muscle proteins in vivo and in vitro / Aldobrando Broccolini and Massimiliano Mirabella
  • Function and structure of VCP mutations leading to h-IBM / Cezary Wojcik
  • Clinical spectrum, including myopathy, Paget's disease, and fronto-temporal dementia : experimental models of VCP mutations, and potential treatments / Virginia Kimonis
  • Animal models of h-IBM due to VCP mutation / Nisha M. Badders and Paul Taylor.