Prototype of a Biomimetic Multi-Spiked Connecting Scaffold for a New Generation of Resurfacing Endoprostheses.

• Author: Uklejewski, Ryszard.
• TeilnehmendeR: Rogala, Piotr.; Winiecki, Mariusz.
• Place / Publishing House: Milton : : Taylor & Francis Group,, 2023.; ©2024.
• Year of Publication: 2023
• Edition: 1st ed.
• Language: English
• Physical Description: 1 online resource (220 pages)

This monograph explains prototype of the biomimetic Multi-Spiked Connecting Scaffold (MSC-Scaffold) fixing in the periarticular bone and the components of a new generation of entirely non-cemented resurfacing arthroplasty (RA) endoprostheses.

Table of Contents

Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Forewords -- Preface -- Acknowledgements -- About the Authors -- Introduction -- Chapter 1 Characteristics of Contemporary hip Resurfacing Arthroplasty Endoprostheses and their Possible Postoperative Complications -- References -- Chapter 2 Idea of Entirely Non-Cemented Implantation of the Components of hip Resurfacing Arthroplasty Endoprostheses with the Multi-Spiked Connecting Scaffold -- References -- Chapter 3 Design, Rapid Prototyping, and Manufacturing of the Biomimetic Multi-Spiked Connecting Scaffold Prototype for Non-Cemented Resurfacing Endoprostheses -- 3.1 Bioengineering CAD Design and Modelling -- 3.2 Methods and Effects of Electro-Erosion Machining -- 3.3 Prototyping Spikes of the Multi-Spiked Connecting Scaffold by Stereolithography -- 3.4 Prototyping and Manufacturing of the Multi-Spiked Connecting Scaffold and the total hip Resurfacing Endoprosthesis by Selective Laser Melting -- 3.5 Post-production Treatment of the Bone-Contacting Surface of the Multi-Spiked Connecting Scaffold -- 3.6 Reverse Design of the Working Prototype of Partial Resurfacing knee Arthroplasty Endoprosthesis -- References -- Chapter 4 Structural and Osteoconductive Functionalization of the Interspike Space of the Prototype Multi-Spiked Connecting Scaffold -- 4.1 Assessment of the Pro-Osteoconductive Potential - Theoretical Basis -- 4.2 Formation of the Structural and Osteoconductive Properties of the Multi-Spiked Connecting Scaffold -- 4.3 Initial Evaluation in cell Culture of Structurally Functionalized Multi-Spiked Connecting Scaffold -- 4.4 Pilot Study of Structurally Functionalized Multi-Spiked Connecting Scaffold in an Animal Model -- References.

Chapter 5 Formation of Osteoinductive and Osseointegrative Properties of the Bone-Contacting Surface of the Multi-Spiked Connecting Scaffold Prototype by the Electrochemical Cathodic Deposition of Calcium Phosphates -- 5.1 Initial Attempts to Modify the Surface of the Multi-Spiked Connecting Scaffold Preprototypes -- 5.2 Research on the Process of Calcium Phosphate Potentiostatic Electrochemical Cathodic Deposition on the Surface of the Spikes with the Subsequent Immersion of the Preprototypes of the Multi-Spiked Connecting Scaffold in a Simulated body Fluid -- 5.3 Evaluation in human Osteoblasts Culture of the Prototype Multi-Spiked Connecting Scaffold with Calcium Phosphate-Modified Bone-Contacting Surface -- 5.4 Biointegration of the Prototype Multi-Spiked Connecting Scaffold with Calcium Phosphate Coating Implanted in Swine knee in Vivo -- References -- Chapter 6 Research on the System of bone and the Prototype Multi-Spiked Connecting Scaffold in order to Design the Structural and Biomechanical Properties of this System -- 6.1 Numerical Study of the Influence of Geometric Features of the Multi-Spiked Connecting Scaffold on the Mechanical Stress Distribution in the Peri-Implant Bone -- 6.2 Validation of the Numerical Model Reflecting the Embedment of the Prototype Multi-Spiked Connecting Scaffold in the Periarticular Bone -- References -- Chapter 7 Pilot Study on the Prototype Multi-Spiked Connecting Scaffold for Non-Cemented Resurfacing Endoprostheses in an Animal Model -- 7.1 Experimental Determination of the Appropriate Surgical Approach to the hip and knee Joint in Swine -- 7.2 Verification of the Working Prototype of Partial Resurfacing knee Arthroplasty Endoprosthesis in ten Experimental Animals -- References.

Chapter 8 Pilot Micro-CT Study of the Impact of Embedding the Multi-Spiked Connecting Scaffold on the Density and Compressive Strength of the Subchondral Trabecular Bone of Femoral heads from Patients with Osteoarthritis -- References -- Chapter 9 Summary, Conclusions, and final Remarks -- Conclusions and final Remarks -- Appendixes -- Appendix 1 - Patents front Pages Scans (US, Canada, Europe) -- Appendix 2 - Letter of thanks from the Rector of the Poznan University of Technology, Poland -- Index.