Basic pharmacokinetics and pharmacodynamics : : an integrated textbook and computer simulations / / edited by Sara E. Rosenbaum.

• VerfasserIn: Rosenbaum, Sara
• TeilnehmendeR: Rosenbaum, Sara
• Place / Publishing House: Hoboken, New Jersey : : John Wiley & Sons, Incorporated,, [2017]; 2017
• Year of Publication: 2017
• Edition: Second edition.
• Language: English
• Physical Description: 1 online resource (757 pages) :; illustrations

Table of Contents

Introduction to pharmacokinetics and pharmacodynamics -- Passage of drugs through membranes -- Drug administration and drug absorption / Steven Sutton -- Drug distribution -- Drug elimination and clearance -- Compartmental models in pharmacokinetics -- Pharmacokinetics of an intravenous bolus injection in a one-compartment model -- Pharmacokinetics of an intravenous bolus injection in a two-compartment model -- Pharmacokinetics of extravascular drug administration / Steven Sutton -- Introduction to noncompartmental analysis -- Pharmacokinetics of intravenous infusion in a one-compartment model -- Multiple intravenous bolus injections in the one-compartment model -- Multiple intermittent infusions -- Multiple oral doses -- Nonlinear pharmacokinetics -- Introduction to pharmacogenetics -- Models used to predict drug-drug interactions for orally administered drugs -- Introduction to physiologically based pharmacokinetic modeling -- Introduction to pharmacodynamic models and integrated pharmacokinetic--pharmacodynamic models / Diane Mould and Paul Hutson -- Semi-mechanistic pharmacokinetic--pharmacodynamic model / Diane Mould and Paul Hutson.