Hemodynamic Adaptation Mechanisms of Heart Failure to Percutaneous Venoarterial Extracorporeal Circulatory Support.

• Author: Hála, Pavel.
• Place / Publishing House: Prague : : Karolinum Press,, 2022.; {copy}2022.
• Year of Publication: 2022
• Edition: 1st ed.
• Language: English
• Physical Description: 1 online resource (92 pages)

Table of Contents

• Cover
• Contents
• Acknowledgments
• Abbreviations
• Abstract
• 1 Introduction
• 1.1 Heart failure
• 1.1.1 Pathophysiology of HF
• 1.1.2 Integration of Cardiac and Vascular Changes
• 1.1.3 Compensatory mechanisms in HF
• 1.1.4 Clinical presentation
• 1.1.5 Therapy and prognosis
• 1.1.6 Acute management strategies
• 1.2 Heart failure models
• 1.3 ECLS
• 1.3.1 Definition of ECLS
• 1.3.2 History of ECLS
• 1.3.3 Indications and incidence of ECMO
• 1.3.4 Anatomy of ECMO
• 1.3.5 Pathophysiology of VA ECMO
• 1.3.6 Monitoring of ECMO circuit
• 1.3.7 Complications of ECMO
• 1.3.8 Hemodynamics of VA ECMO
• 2 Hypotheses
• 3 Aims
• 4 Methodology
• 4.1 Animal model of chronic heart failure
• 4.2 Animal model of acute HF induced by regionalcoronary hypoxemia
• 4.3 Animal model of acute HF induced by globalcoronary hypoxemia
• 4.4 Animal model of right-sided HF
• 4.5 Experimental preparation and hemodynamicmonitoring
• 4.6 Left ventricular parameters and stroke workanalysis
• 4.7 ECMO instrumentation
• 4.8 Experimental ECMO protocols and data acquisition
• 4.9 Statistical analysis
• 5 Results
• 5.1 Characteristics of developed chronic HF model
• 5.2 Characteristics of acute HF model induced byregional coronary hypoxemia
• 5.3 Characteristics of acute HF model induced byglobal coronary hypoxemia
• 5.4 Characteristics of right-sided HF model
• 5.5 Effects of EBF on chronic HF
• 5.6 Effects of EBF on acute HF
• 6 Discussion
• 6.1 Comments on HF animal models
• 6.2 EBF effects on chronic HF
• 6.3 EBF effects on acute HF
• 6.4 Correlation of tissue saturation and perfusion
• 6.5 Effects of flow pulsatility
• 6.6 Clinical considerations
• 6.7 Study limitations
• 7 Conclusions
• 8 List of linked documents
• 9 References.