A Comprehensive Guide to Nanoparticles in Medicine.

• Author: Acharya, Rituparna.
• Place / Publishing House: Sharjah : : Bentham Science Publishers,, 2021.; Ã2021.
• Year of Publication: 2021
• Edition: 1st ed.
• Language: English
• Physical Description: 1 online resource (199 pages)

Table of Contents

Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- Acknowledgements -- Introduction of Nanoparticles in Medicine -- INTRODUCTION -- REFERENCES -- The Procedure of Synthesis of Nanoparticles Used as Diagnostics and Therapy Available till Date -- INTRODUCTION -- CHEMICAL METHODS OF NANOPARTICLE SYNTHESIS -- Co-Precipitation -- Sol-Gel Method -- Microemulsion Method -- Hydrothermal Technique -- Polyol Synthesis -- Microwave Assisted Synthesis -- Chemical Vapor Deposition (CVD) &amp -- Chemical Vapor Synthesis (CVS) -- Plasma Enhanced Chemical Vapor Deposition (PECVD) -- PHYSICAL METHODS OF NANOPARTICLE SYNTHESIS -- High Energy Ball Milling -- Inert Gas Condensation -- Physical Vapor Deposition -- Laser Pyrolysis -- Flame Spray Pyrolysis -- Electrospraying -- Melt Blending -- BIO-ASSISTED METHODS -- Biogenic Synthesis Using Microorganisms -- Biogenic Synthesis Using Bio-molecules as the Templates -- Biogenic Synthesis Using Plant Extracts -- CONCLUSION -- REFERENCES -- Recent Progress of Nanoparticles Used in the Diagnosis of Different Types of Diseases -- INTRODUCTION -- NANOPARTICLE BASED DIAGNOSIS -- Emission-Based Detection -- Fluorescence-Based Detection -- Colorimetric Detection -- Microarray Detection -- Magnetic-Based Detection -- Magnetic Resonance Imaging (MRI) -- Nuclear Magnetic Resonance (NMR) -- Electrochemical-Based Detection -- Gold Nanoparticles -- Silver Nanoparticle -- Quantum Dot Nanoparticles -- Cerium oxide nanoparticles (CeO2 NPs) -- Mercury Selenide Nanoparticles (HgSe NPs) -- Copper-based Nanoparticles (CuNPs) -- Plasmonics-Based Detection -- Surface-Enhanced Raman Scattering (SERS) -- Surface-Enhanced Infrared Absorption (SEIRA) -- Metal Enhanced Fluorescence (MEF) -- CONCLUSION -- REFERENCES.

Drug Delivery through Nanoparticle in Treatment of Diseases -- INTRODUCTION -- CHARACTERISTICS OF NANOPARTICLE FOR THE FABRICATION OF DRUG DELIVERY VEHICLE -- Size of Nanoparticles -- Surface Property of Nanoparticles -- Drug Loading and Release From the Nanoparticle -- APPLICATION OF NANOPARTICLES IN DRUG DELIVERY -- Cancer Therapy -- HIV and AIDS Treatment -- Nutraceutical Delivery Through Nanoparticles -- NANOCARRIERS FOR DRUG DELIVERY -- Organic Polymer Based Nanocarriers -- Chitosan -- Alginate -- Xanthan Gum -- Cellulose -- Liposomes -- Dendrimers -- Inorganic Nanoparticles -- Carbon Nanotubes -- Gold Nanoparticles -- Quantum Dots -- Superparamagnetic Iron-Oxide Nanoparticles -- Silica Nanoparticles -- CONCLUSION -- REFERENCES -- Nanoparticle-DNA Conjugate: The Treatment and Diagnostic Option for Future Cure of Diseases -- INTRODUCTION -- DNA-NANOPARTICLE CONJUGATES IN NANOMEDICINE -- DNA-Gold Nanoparticle Conjugate -- Binding Between DNA and Gold Nanoparticle -- Application of DNA-Gold Nanoconjugate in Nucleic Acid Detection -- Application of DNA-Gold Nanoparticle for Colorimetric Detection of Miscellaneous Analytes -- Application of DNA-Gold Nanoconjugate for Gene And Drug Delivery -- DNA-Silver Conjugate Nanoparticle -- Plasmonic Application of DNA-Silver Nanoconjugate -- DNA-Magnetic Nanoparticle -- Gene Therapy -- Fluorescence Detection Method -- DNA-Platinum and Palladium Nanoparticles -- Electrochemical Detection -- DNA Detection in Chip Based Microarrays -- DNA-Quantum Dots Nanoconjugate -- Biosensing Application -- Gene Delivery and Therapeutics -- DNA-Carbon Nanotubes -- Chemical Biosensors -- Detection of Nucleic Acid Sequence -- Biological Transporters -- DNA-Chitosan Nanoparticle -- Gene Therapy -- CONCLUSION -- REFERENCES -- Nanoparticle Conjugated with siRNA for Treatment of Different Types of Disease Conditions -- INTRODUCTION.

siRNAs as Potential Therapeutics -- CHALLENGES IN DELIVERY OF SIRNA -- Administrative Barrier -- Vascular Barrier -- Cellular Barriers -- Immune Response and Safety -- OVERCOMING THE MAJOR BARRIERS FOR SIRNA DELIVERY -- Intravenous Administration -- Optimization of the Size of the siRNA Nanocarrier -- Endocytosis of siRNA-nanoparticle Conjugate -- Overcoming the Immune Response -- NANOPARTICLE IN SIRNA THERAPY -- siRNA-silica Based Nanoconjugate -- siRNA-metal and Metal Oxide Nanoconjugates -- siRNA-carbon Based Nanoconjugates -- siRNA-dendrimer Nanoconjugates -- siRNA-polymer Nanoconjugate -- siRNA-Cyclodextrin Nanoconjugate -- siRNA-lipid Based Nanoconjugates -- siRNA-hydrogel Nanoconjugate -- siRNA-quantum Dot Nanoconjugate -- CONCLUSION -- REFERENCES -- shRNA-Nanoparticle Conjugate as a Therapeutic Option -- INTRODUCTION -- SHRNA-NANOPARTICLE CONJUGATES -- Inorganic Nanoconjugates -- Organic Nanoconjugates -- Polymeric Nanoconjugates -- Other Nanoparticle Conjugates -- CONCLUSION -- REFERENCES -- miRNA and Nanoparticle Conjugate as a Future Therapeutic Approach -- INTRODUCTION -- Tissue Specific Expression -- Circulation miRNAs -- THERAPEUTIC APPROACHES USING MIRNAS -- miRNA Suppression Therapy -- miRNA Replacement Therapy -- CHALLENGES IN MIRNA BASED THERAPIES -- Instability within Blood Vascular System -- Reduced Intracellular Delivery -- Off Target Effects -- NANOPARTICLE ASSISTED MIRNA DELIVERY -- Inorganic Nanoparticle Based Delivery of miRNA and Anti-miRNA -- Gold Nanoconjugate -- Graphine Nanoconjugate -- Mesoporous Silica Nanoconjugate -- Quantum Dot Nanoconjugate -- Magnetic Nanoconjugate -- Organic Nanoparticle Based Delivery of miRNA and Anti-miRNA -- Chitosan Based Nanoconjugate -- Lipid/liposome Based Nanoconjugate -- Protein or Peptide Based Nanoconjugate -- Aptamers Nanoconjugate.

Polymeric Nanoparticle Based Delivery of miRNA and Anti-miRNA -- Polyethyleneimine Nanoconjugate -- Dendrimer Nanoconjugate -- PLGA Based Nanoconjugate -- Cyclodextrin Nanoconjugate -- CHALLENGES WITH RNA NANOTECHNOLOGY -- Challenge in RNA Structure Prediction -- Stability of the Nanoconjugate -- In Vivo Half-life and Retention Time of the Nanoconjugate -- Limited Carrying Capacity of the Nanoparticle -- Scaling Up of the Conjugate -- Hurdles in Endosomal Escape of the Payload -- CONCLUSION -- REFERENCES -- Nanoparticle Immunotherapy -- INTRODUCTION -- NANOPARTICLES IN IMMUNOTHERAPY -- Antigen Delivery by Nanoparticles -- Adjuvant Delivery by Nanoparticles -- Co-delivery of Antigen and Adjuvant by Nanoparticles -- Activation of Dendritic Cells by Nanoparticles -- Change of Tumor Microenvironment by Nanoparticles -- Delivery of Antibodies by Nanoparticles -- Gene Delivery by Nanoparticles -- Cytokine Delivery by Nanoparticles -- Therapeutic Cellular Engineering by Nanoparticles -- Overcoming Immunosuppression by Nanoparticles -- Immune Check Point Inhibition by Nanoparticles -- Induced Immunogenic Cell Death by Nanoparticles -- TYPES OF NANOPARTICLES IN IMMUNOTHERAPY -- Inorganic Nanoparticles -- Organic Nanoparticles -- Polymeric Nanoparticles -- CONCLUSION -- REFERENCES -- Nanoparticle Vaccines -- INTRODUCTION -- CHARACTERIZATION OF NANOVACCINES -- Size -- Surface Charge -- Shape -- Hydrophobicity -- Surface Modification -- NANOPARTICLE VACCINES -- Inorganic Nanoconjugates -- Organic Nanoconjugates -- Polymeric Nanoconjugates -- IMMUNE STIMULATOR USING NANOCARRIER -- Cytokines -- Toll Like Receptor Agonists -- Nucleic Acids -- CONCLUSION -- REFERENCES -- Conclusion -- Glossary -- ABBREVIATIONS -- Subject Index -- Back Cover.