Gene discovery for disease models / edited by Weikuan Gu.

• Author: ProQuest (Firm)
• TeilnehmendeR: Gu, Weikuan.; ProQuest (Firm)
• Year of Publication: 2011
• Language: English
• Physical Description: xiii, 537 p., [15] p. of plates :; col. ill.

Table of Contents

• Introduction : gene discovery-from positional cloning to genomic cloning
• High throughput gene expression analysis and the identification of expression QTLs
• DNA methylation in the pathogenesis of autoimmunity
• Ccell-based analysis with microfluidic chip
• Missing dimension : protein turnover rate measurement in gene discovery
• Bioinformatics tools for the prediction of gene function
• Determination of genomic locations of targeted genetic loci
• Mutation discovery using high throughput mutation screening technology
• Candidate screening through gene expression profile
• Candidate screening through high-density SNP array
• Gene discovery through direct genome sequencing
• Candidate screening through bioinformatics tools
• Using an integrative strategy to identify mutations
• Determination of the function of a mutant in a gene
• Confirmation of a mutation by multiple molecular approaches
• Confirmation of a mutation by microRNA
• Confirmation of function of a gene by translational approaches
• Confirmation of single nucleotide mutations
• Initial identification and confirmation of a QTL gene
• Gene discovery of crop diseases in the post genome era
• Impact of whole genome genetic element analysis on gene discovery of disease models
• Impact of whole genome protein analysis on gene discovery of disease models.