Genome Editing in Neurosciences.
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Superior document: | Research and Perspectives in Neurosciences Series |
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Place / Publishing House: | Cham : : Springer International Publishing AG,, 2017. ©2017. |
Year of Publication: | 2017 |
Edition: | 1st ed. |
Language: | English |
Series: | Research and Perspectives in Neurosciences Series
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Physical Description: | 1 online resource (129 pages) |
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Jaenisch, Rudolf. Genome Editing in Neurosciences. 1st ed. Cham : Springer International Publishing AG, 2017. ©2017. 1 online resource (129 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Research and Perspectives in Neurosciences Series Intro -- Preface -- Contents -- List of Contributors -- In Vitro Modeling of Complex Neurological Diseases -- Introduction -- Induced Pluripotent Stem Cells to Model Complex Diseases -- Gene Editing to Generate Genetically Controlled Disease Models -- Functional Role of GWAS-Identified Risk Variants in Complex Disease -- Epigenomic Signatures to Prioritize GWAS-Identified Risk Variants -- Functional Analysis of Parkinsonś Disease-Associated Risk Variants -- Identification of Parkinsonś Disease-Associated Risk Variants in Brain-Specific Enhancer Elements -- Allele-Specific Gene Expression as a Robust Read-Out to Analyze Cis-Regulatory Effects -- Functional Analysis of Parkinsonś-Associated Risk Variants -- Mechanistic Study of Sporadic Diseases: Conclusions -- References -- Aquatic Model Organisms in Neurosciences: The Genome-Editing Revolution -- Introduction -- Zebrafish: With the CRiSPR-Cas9 System, Forward Genetic Screens Are Back Again -- Optimizing the Cripsr-Cas9 System in Transparent Marine Animals -- More and More Aquatic Model Organisms for Diversified Uses -- In Biomedical Research, Why and How Should We Use Aquatic Models to Study Diseases of the Nervous System? -- A Short Natural History of the Nervous System: Several Questions on Its Origin -- Conclusion -- References -- Genome-Wide Genetic Screening in the Mammalian CNS -- Introduction -- Genome-Wide Viral Library Preparation and Delivery -- Interpretation of Results -- Future Directions -- References -- CRISPR/Cas9-Mediated Knockin and Knockout in Zebrafish -- CRISPR/Cas9 and Gal4/UAS Combination for Cell-Specific Gene Inactivation -- Crispr/Cas9-Mediated Knockin Approaches in Zebrafish -- References -- Dissecting the Role of Synaptic Proteins with CRISPR -- Introduction -- Genome Editing Using CRISPR/Cas9 -- Practical Considerations for the Use of CRISPR/Cas9. The Use of CRISPR/Cas9 in Neurons: Proof of Concept -- Conclusions and Future Perspectives -- References -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- References -- Neuroscience Research Using Non-human Primate Models and Genome Editing -- Introduction -- Characteristics of the Common Marmoset -- Advantages of Using Common Marmosets for Biomedical Research -- Transgenic Techniques and Genome Editing Technology for Marmoset Research -- Future Perspectives -- References -- Multiscale Genome Engineering: Genome-Wide Screens and Targeted Approaches -- Introduction -- Top-Down Approaches Using Genome-Wide CRISPR Screens -- Bottom-Up Approaches Using Exome Sequencing in Autism -- References -- Using Genome Engineering to Understand Huntingtonś Disease -- Huntington ́Disease -- Gene Editing Enzymes -- Uses for Gene Editing to Understand Human Diseases -- Gene Editing In Vivo to Treat Genetic Diseases -- Conclusion -- References -- Therapeutic Gene Editing in Muscles and Muscle Stem Cells -- Duchenne Muscular Dystrophy -- Current Gene-Targeted Therapeutic Strategies for DMD -- Challenges for Therapeutic Exon Skipping and Microdystrophin Delivery Strategies -- Gene-Editing Approaches to Restore Dystrophin Function in DMD -- Remaining Challenges for Therapeutic Development of DMD-CRISPR -- Challenges of DMD-CRISPR Delivery -- Potential Immune Response to Restored Dystrophin Protein -- Pre-existing and Acquired Immunity to Cas9 -- Assessing Mutagenic Events at On-Target and Off-Target Sites -- Enabling HR for Precise Repair of Dmd -- Gene-Editing Therapy in Combination with AONs or Microdystrophin -- Possible Application of CRISPR-mediated gene editing Strategies in Other Diseases -- Conclusions and Perspective -- References. Description based on publisher supplied metadata and other sources. Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. Electronic books. Zhang, Feng. Gage, Fred. Print version: Jaenisch, Rudolf Genome Editing in Neurosciences Cham : Springer International Publishing AG,c2017 9783319601915 ProQuest (Firm) https://ebookcentral.proquest.com/lib/oeawat/detail.action?docID=6422738 Click to View |
language |
English |
format |
eBook |
author |
Jaenisch, Rudolf. |
spellingShingle |
Jaenisch, Rudolf. Genome Editing in Neurosciences. Research and Perspectives in Neurosciences Series Intro -- Preface -- Contents -- List of Contributors -- In Vitro Modeling of Complex Neurological Diseases -- Introduction -- Induced Pluripotent Stem Cells to Model Complex Diseases -- Gene Editing to Generate Genetically Controlled Disease Models -- Functional Role of GWAS-Identified Risk Variants in Complex Disease -- Epigenomic Signatures to Prioritize GWAS-Identified Risk Variants -- Functional Analysis of Parkinsonś Disease-Associated Risk Variants -- Identification of Parkinsonś Disease-Associated Risk Variants in Brain-Specific Enhancer Elements -- Allele-Specific Gene Expression as a Robust Read-Out to Analyze Cis-Regulatory Effects -- Functional Analysis of Parkinsonś-Associated Risk Variants -- Mechanistic Study of Sporadic Diseases: Conclusions -- References -- Aquatic Model Organisms in Neurosciences: The Genome-Editing Revolution -- Introduction -- Zebrafish: With the CRiSPR-Cas9 System, Forward Genetic Screens Are Back Again -- Optimizing the Cripsr-Cas9 System in Transparent Marine Animals -- More and More Aquatic Model Organisms for Diversified Uses -- In Biomedical Research, Why and How Should We Use Aquatic Models to Study Diseases of the Nervous System? -- A Short Natural History of the Nervous System: Several Questions on Its Origin -- Conclusion -- References -- Genome-Wide Genetic Screening in the Mammalian CNS -- Introduction -- Genome-Wide Viral Library Preparation and Delivery -- Interpretation of Results -- Future Directions -- References -- CRISPR/Cas9-Mediated Knockin and Knockout in Zebrafish -- CRISPR/Cas9 and Gal4/UAS Combination for Cell-Specific Gene Inactivation -- Crispr/Cas9-Mediated Knockin Approaches in Zebrafish -- References -- Dissecting the Role of Synaptic Proteins with CRISPR -- Introduction -- Genome Editing Using CRISPR/Cas9 -- Practical Considerations for the Use of CRISPR/Cas9. The Use of CRISPR/Cas9 in Neurons: Proof of Concept -- Conclusions and Future Perspectives -- References -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- References -- Neuroscience Research Using Non-human Primate Models and Genome Editing -- Introduction -- Characteristics of the Common Marmoset -- Advantages of Using Common Marmosets for Biomedical Research -- Transgenic Techniques and Genome Editing Technology for Marmoset Research -- Future Perspectives -- References -- Multiscale Genome Engineering: Genome-Wide Screens and Targeted Approaches -- Introduction -- Top-Down Approaches Using Genome-Wide CRISPR Screens -- Bottom-Up Approaches Using Exome Sequencing in Autism -- References -- Using Genome Engineering to Understand Huntingtonś Disease -- Huntington ́Disease -- Gene Editing Enzymes -- Uses for Gene Editing to Understand Human Diseases -- Gene Editing In Vivo to Treat Genetic Diseases -- Conclusion -- References -- Therapeutic Gene Editing in Muscles and Muscle Stem Cells -- Duchenne Muscular Dystrophy -- Current Gene-Targeted Therapeutic Strategies for DMD -- Challenges for Therapeutic Exon Skipping and Microdystrophin Delivery Strategies -- Gene-Editing Approaches to Restore Dystrophin Function in DMD -- Remaining Challenges for Therapeutic Development of DMD-CRISPR -- Challenges of DMD-CRISPR Delivery -- Potential Immune Response to Restored Dystrophin Protein -- Pre-existing and Acquired Immunity to Cas9 -- Assessing Mutagenic Events at On-Target and Off-Target Sites -- Enabling HR for Precise Repair of Dmd -- Gene-Editing Therapy in Combination with AONs or Microdystrophin -- Possible Application of CRISPR-mediated gene editing Strategies in Other Diseases -- Conclusions and Perspective -- References. |
author_facet |
Jaenisch, Rudolf. Zhang, Feng. Gage, Fred. |
author_variant |
r j rj |
author2 |
Zhang, Feng. Gage, Fred. |
author2_variant |
f z fz f g fg |
author2_role |
TeilnehmendeR TeilnehmendeR |
author_sort |
Jaenisch, Rudolf. |
title |
Genome Editing in Neurosciences. |
title_full |
Genome Editing in Neurosciences. |
title_fullStr |
Genome Editing in Neurosciences. |
title_full_unstemmed |
Genome Editing in Neurosciences. |
title_auth |
Genome Editing in Neurosciences. |
title_new |
Genome Editing in Neurosciences. |
title_sort |
genome editing in neurosciences. |
series |
Research and Perspectives in Neurosciences Series |
series2 |
Research and Perspectives in Neurosciences Series |
publisher |
Springer International Publishing AG, |
publishDate |
2017 |
physical |
1 online resource (129 pages) |
edition |
1st ed. |
contents |
Intro -- Preface -- Contents -- List of Contributors -- In Vitro Modeling of Complex Neurological Diseases -- Introduction -- Induced Pluripotent Stem Cells to Model Complex Diseases -- Gene Editing to Generate Genetically Controlled Disease Models -- Functional Role of GWAS-Identified Risk Variants in Complex Disease -- Epigenomic Signatures to Prioritize GWAS-Identified Risk Variants -- Functional Analysis of Parkinsonś Disease-Associated Risk Variants -- Identification of Parkinsonś Disease-Associated Risk Variants in Brain-Specific Enhancer Elements -- Allele-Specific Gene Expression as a Robust Read-Out to Analyze Cis-Regulatory Effects -- Functional Analysis of Parkinsonś-Associated Risk Variants -- Mechanistic Study of Sporadic Diseases: Conclusions -- References -- Aquatic Model Organisms in Neurosciences: The Genome-Editing Revolution -- Introduction -- Zebrafish: With the CRiSPR-Cas9 System, Forward Genetic Screens Are Back Again -- Optimizing the Cripsr-Cas9 System in Transparent Marine Animals -- More and More Aquatic Model Organisms for Diversified Uses -- In Biomedical Research, Why and How Should We Use Aquatic Models to Study Diseases of the Nervous System? -- A Short Natural History of the Nervous System: Several Questions on Its Origin -- Conclusion -- References -- Genome-Wide Genetic Screening in the Mammalian CNS -- Introduction -- Genome-Wide Viral Library Preparation and Delivery -- Interpretation of Results -- Future Directions -- References -- CRISPR/Cas9-Mediated Knockin and Knockout in Zebrafish -- CRISPR/Cas9 and Gal4/UAS Combination for Cell-Specific Gene Inactivation -- Crispr/Cas9-Mediated Knockin Approaches in Zebrafish -- References -- Dissecting the Role of Synaptic Proteins with CRISPR -- Introduction -- Genome Editing Using CRISPR/Cas9 -- Practical Considerations for the Use of CRISPR/Cas9. The Use of CRISPR/Cas9 in Neurons: Proof of Concept -- Conclusions and Future Perspectives -- References -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- References -- Neuroscience Research Using Non-human Primate Models and Genome Editing -- Introduction -- Characteristics of the Common Marmoset -- Advantages of Using Common Marmosets for Biomedical Research -- Transgenic Techniques and Genome Editing Technology for Marmoset Research -- Future Perspectives -- References -- Multiscale Genome Engineering: Genome-Wide Screens and Targeted Approaches -- Introduction -- Top-Down Approaches Using Genome-Wide CRISPR Screens -- Bottom-Up Approaches Using Exome Sequencing in Autism -- References -- Using Genome Engineering to Understand Huntingtonś Disease -- Huntington ́Disease -- Gene Editing Enzymes -- Uses for Gene Editing to Understand Human Diseases -- Gene Editing In Vivo to Treat Genetic Diseases -- Conclusion -- References -- Therapeutic Gene Editing in Muscles and Muscle Stem Cells -- Duchenne Muscular Dystrophy -- Current Gene-Targeted Therapeutic Strategies for DMD -- Challenges for Therapeutic Exon Skipping and Microdystrophin Delivery Strategies -- Gene-Editing Approaches to Restore Dystrophin Function in DMD -- Remaining Challenges for Therapeutic Development of DMD-CRISPR -- Challenges of DMD-CRISPR Delivery -- Potential Immune Response to Restored Dystrophin Protein -- Pre-existing and Acquired Immunity to Cas9 -- Assessing Mutagenic Events at On-Target and Off-Target Sites -- Enabling HR for Precise Repair of Dmd -- Gene-Editing Therapy in Combination with AONs or Microdystrophin -- Possible Application of CRISPR-mediated gene editing Strategies in Other Diseases -- Conclusions and Perspective -- References. |
isbn |
9783319601922 9783319601915 |
callnumber-first |
R - Medicine |
callnumber-subject |
RB - Pathology |
callnumber-label |
RB155-155 |
callnumber-sort |
RB 3155 3155.8 |
genre |
Electronic books. |
genre_facet |
Electronic books. |
url |
https://ebookcentral.proquest.com/lib/oeawat/detail.action?docID=6422738 |
illustrated |
Not Illustrated |
dewey-hundreds |
600 - Technology |
dewey-tens |
610 - Medicine & health |
dewey-ones |
616 - Diseases |
dewey-full |
616.80442 |
dewey-sort |
3616.80442 |
dewey-raw |
616.80442 |
dewey-search |
616.80442 |
oclc_num |
1004664421 |
work_keys_str_mv |
AT jaenischrudolf genomeeditinginneurosciences AT zhangfeng genomeeditinginneurosciences AT gagefred genomeeditinginneurosciences |
status_str |
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ids_txt_mv |
(MiAaPQ)5006422738 (Au-PeEL)EBL6422738 (OCoLC)1004664421 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Research and Perspectives in Neurosciences Series |
is_hierarchy_title |
Genome Editing in Neurosciences. |
container_title |
Research and Perspectives in Neurosciences Series |
author2_original_writing_str_mv |
noLinkedField noLinkedField |
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