Self-Assembled Molecules - New Kind of Protein Ligands : : Supramolecular Ligands.

• Author: Roterman, Irena.
• TeilnehmendeR: Konieczny, Leszek.
• Place / Publishing House: Cham : : Springer International Publishing AG,, 2017.; ©2018.
• Year of Publication: 2017
• Edition: 1st ed.
• Language: English
• Physical Description: 1 online resource (145 pages)

Table of Contents

Intro -- Foreword -- Acknowledgements -- Contents -- Abbreviations -- Chapter 1: Supramolecular Systems as Protein Ligands -- 1.1 Mechanism of Complexation -- 1.2 Structural Adaptability of Molecules Forming Supramolecular Structures -- 1.3 Specificity of Congo Red Complexation -- References -- Chapter 2: Supramolecular Congo Red as Specific Ligand of Antibodies Engaged in Immune Complex -- 2.1 Looking for Evidence of Postulated Intra-molecular Immunological Signaling -- 2.2 Evidences of Intramolecular Signaling Supplied by Using Congo Red -- 2.3 Application of Congo Red for Immunotargeting -- 2.4 Toxicity of CR and Its Applicability for Immunotargeting -- References -- Chapter 3: Protein Conditioning for Binding Congo Red and Other Supramolecular Ligands -- 3.1 Natural Susceptibility of Proteins to Bind Congo Red -- 3.2 Interaction of Congo Red with Helical Structures of Polypeptides -- 3.3 Fluorescence Property of Congo Red -- References -- Chapter 4: Metal Ions Introduced to Proteins by Supramolecular Ligands -- 4.1 Metal Ions in Natural Biological Systems -- 4.2 Insertion of Metal Ions into Proteins by Supramolecular Ligands -- 4.3 Conclusions -- References -- Chapter 5: Possible Mechanism of Amyloidogenesis of V Domains -- 5.1 Characteristics of Immunoglobulin Domains -- 5.2 Target Proteins -- 5.3 The Fuzzy Oil Drop Model -- 5.4 Structure of Hydrophobic Core in B-J Proteins -- 5.4.1 Dimers of L-L Chains in Bence-Jones Proteins and of L-H Chains in the Fab Fragment -- 5.4.2 V(L)-V(L), C(L)-C(L), V(H)-V(L) and C(H)-C(L) Dimers -- 5.4.3 Individual Domains -- 5.5 Role of the N-Terminal Fragment in V Domains -- 5.6 Hypothetical Amyloidogenesis Mechanism Affecting the V Domain in B-J Proteins -- 5.7 Complexation of Congo Red -- 5.8 Hypothetical Amyloidogenesis of V Domains -- References.

Chapter 6: Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy -- 6.1 Introduction -- 6.2 Silver Complexes with TY in the Supramolecular CR System -- 6.3 Antimicrobial and Antifungal Activity of Silver Ion Complexes with Titan Yellow (TY/Ag+) and TY/Ag+ Complexes with Congo Red (CR/TY/Ag+) -- 6.3.1 Methodology -- 6.3.2 Results -- 6.4 Determination of the Effect of TY/Ag+ and CR/TY/Ag+ on Antibiotic Activity on Selected Standard and Clinical Bacterial Strains -- 6.5 Cytotoxicity Analysis of the TY/Ag+ Complex -- 6.6 Summary -- References -- Chapter 7: Congo Red Interactions with Single-Walled Carbon Nanotubes -- 7.1 Methods of Dispersing Carbon Nanotubes - The Search for Optimal Dispersion Methods -- 7.2 The Interaction of Congo Red with Carbon Nanotubes -- 7.3 The Incorporation of Other Compounds by SWNT-CR Complexes - Examples of Possible Biomedical Use -- References -- Erratum -- Index.