Advancing the Science of Cancer in Latinos.

• Author: Ramirez, Amelie G.
• TeilnehmendeR: Trapido, Edward J.
• Place / Publishing House: Cham : : Springer International Publishing AG,, 2019.; ©2020.
• Year of Publication: 2019
• Edition: 1st ed.
• Language: English
• Physical Description: 1 online resource (320 pages)

Table of Contents

Intro -- Preface -- Acknowledgments -- Contents -- Contributors -- About the Editors -- Part I: Introduction -- Chapter 1: Advancing the Science of Cancer in Latinos -- Introduction -- Part II: Genetics, Environment, Lifestyle, and Cancer -- Part III: Cancer Risk, Prevention, and Screening -- Part IV: The Biology of Cancer Health Disparities -- Gastric Cancer -- Breast Cancer -- Part V: Advances in Cancer Therapy and Clinical Trials -- Part VI: Cancer in the Era of Precision Medicine -- Part VII: Cancer Outcomes and Survivorship in Latinos -- Part VIII: Engaging Latinos in Cancer Research -- Conclusion -- References -- Part II: Genetics, Environment, Lifestyle, and Cancer -- Chapter 2: Disaggregated Hispanic Groups and Cancer: Importance, Methodology, and Current Knowledge -- Introduction -- Epidemiology of Cancer in Hispanics: Aggregated -- Epidemiology of Cancer in Disaggregated Hispanic Groups -- Challenges in the Data -- Challenges in the Analyses -- Survival Estimation Problems for Disaggregated Hispanic Groups -- Current Knowledge: Cancer in Hispanic Groups, Based on Mortality Data -- Conclusions -- References -- Chapter 3: Colorectal Cancer Disparities in Latinos: Genes vs. Environment -- Overview of Colorectal Cancer Disparities in Hispanics -- Factors Contributing to Colorectal Cancer Disparities in Puerto Rican Hispanics -- Epidemiology -- Environmental Factors -- Genetics -- Summary -- References -- Part III: Cancer Risk, Prevention, and Screening -- Chapter 4: Breast Cancer Risk and Mortality in Women of Latin American Origin -- Introduction -- Breast Cancer Risk in Women of Latin American Origin -- Breast Cancer Mortality in Women of Latin American Origin -- Breast Tumor Subtypes in Women of Latin American Origin.

Gaps: Do We Have the Right Data to Learn to Predict, Prevent, and Treat Breast Cancer in Women of Latin American Origin? -- References -- Chapter 5: Prostate Cancer in US Latinos: What Have We Learned and Where Should We Focus Our Attention -- Prostate Cancer Among Latinos -- Prostate Cancer Incidence and Etiology -- Clinical Presentation of PCa Among Latinos -- PCa Treatment Patterns Among Latinos -- Survival and Mortality -- Final Conclusions and Key Knowledge Gaps to Address -- References -- Chapter 6: Differential Cancer Risk in Latinos: The Role of Diet -- Introduction -- Cancer Incidence Varies by Ethnicity and Gender -- Dietary Factors and Cancer Risk -- Dietary Patterns and Cancer Risk -- References -- Part IV: The Biology of Cancer Health Disparities -- Chapter 7: Biomarkers of Gastric Premalignant Lesions -- Epidemiology -- Etiology -- H. pylori -- Environmental Factors -- Genetic Bases of the Gastric Inflammatory Cascade (Correa's Cascade) -- Single-Nucleotide Polymorphisms (SNPs) -- Stage-Specific and Evolution-Associated Gene Profiles -- References -- Chapter 8: Molecular Subtypes and Driver Mutations in Latinos with Gastric Cancer: Implications for Etiological and Translational Research -- Gastric Cancer Is a Common Malignancy with Poor Outcomes -- Gastric Cancer in Latinos -- Genomic and Genetic Research Disparities -- The Unique Epidemiology of Gastric Cancer in Latinos -- Molecular GC Profiles in Latinos Are Unique -- Conclusions -- References -- Chapter 9: The Biology of Breast Cancer Disparities in Hispanics: Current Knowledge, Gaps, and Research Opportunities -- Introduction -- Factors Contributing to Higher Breast Cancer Mortality Among Hispanics -- Recent Data Elucidating the Causes of Breast Cancer Disparities Among Hispanics -- Breast Cancer in Young Hispanic Women: The Subset with the Greatest Disparities in Outcomes.

Conclusions from Recent Data -- Hypothesis for the Causes of Early Onset Breast Cancer Disparities and the Potential Role of Childhood Obesity -- Childhood Obesity: A Likely Contributor to Breast Cancer Disparities -- Possible Linkage of Childhood Obesity with Breast Cancer: The Third Harvard Growth Study -- Childhood Obesity: A Proinflammatory State with High Estrogen and Genotoxic Estrogen Levels -- Contemporary Hormonal Contraception Is Associated with a Higher Risk of Breast Cancer -- Oral Versus Transdermal Estrogen Replacement and Its Effects on Estrogen Metabolism -- Future Research on Genotoxic Estrogen Metabolites and Breast Cancer Disparities -- Conclusions -- References -- Chapter 10: Molecular Profiles of Breast Cancer in Hispanic/Latina -- Introduction -- Breast Cancer Intrinsic Subtypes -- Genetic Ancestry and Breast Cancer Characteristics -- Conclusions -- References -- Part V: Advances in Cancer Therapy and Clinical Trials -- Chapter 11: Biomarkers and Precision Medicine in Oncology Practice and Clinical Trials -- Introduction: Biomarkers in Clinical Care and Research -- Biomarker-Based Precision Medicine -- Biomarkers for Decision Support -- Biomarker Properties -- Considerations in Biomarker-Driven Trial Design -- Tumor Sequencing for the Near Future -- FDA Approvals of Next-Generation Gene Sequencing (NGS) Panels and In Vitro Diagnostics (IVDs) -- Designing Clinical Trials to Support FDA Approval -- Cancer Immunotherapy (CIT) Biomarkers -- General Concepts -- Program for Accelerated Cancer Therapies (PACT): An Example of Multidisciplinary Collaboration to Elucidate Relevant Biomarkers in Oncology -- Challenges and Opportunities to Improve Biomarker-Based Trials -- Chapter 12: Overcoming Barriers for Latinos on Cancer Clinical Trials -- Increasing Complexity of Accrual in Clinical Trials for All Populations.

Barriers That May Disproportionately Impact Latino Patient Enrollment -- Strategies to Facilitate Clinical Trial Participation -- Next Steps -- References -- Part VI: Cancer in the Era of Precision Medicine -- Chapter 13: Breast Cancer Precision Medicine in Hispanics/Latinas: Focus on Luminal B Tumors -- Introduction -- Hispanics/Latinas and Breast Cancer: A Complex Relationship -- Luminal B Breast Cancer in Colombians -- Discussion -- References -- Chapter 14: Is Precision Medicine Widening Cancer Care Disparities in Latino Populations? The Rutgers Cancer Institute of New Jersey Experience -- Introduction -- Background -- Latino Populations in the United States -- Latino Populations in New Jersey -- Targeted Therapies as Standard of Care -- Cancer Incidence and Mortality Rates Among Patients of Latino Ancestry -- Our Experience -- Next-Generation Sequencing (NGS) -- Results -- Discussion -- References -- Part VII: Cancer Outcomes and Survivorship in Latinos -- Chapter 15: A Vision for Improving Quality of Life Among Spanish-Speaking Latina Breast Cancer Survivors -- Introduction -- State of the Science on Behavioral Interventions to Improve Health-Related Quality of Life Among Latino Cancer Survivors -- The Nuevo Amanecer Program and Translation Methods -- Rationale -- Translation of the Nuevo Amanecer Program -- A Conceptual Framework to Guide Research on Behavioral Interventions for Latino Cancer Survivors -- Gaps and Opportunities for Future Research -- Conclusions -- References -- Chapter 16: Research Democracy in a Randomized Controlled Trial: Engaging Multiple Stakeholders in Patient-Centered Outcomes Research -- Introduction -- Methods -- Results -- Discussion -- References -- Part VIII: Engaging Latinos in Cancer Research -- Chapter 17: Es Tiempo: Engaging Latinas in Cervical Cancer Research -- Overview of Community-Driven Research.

Current Work -- Past Interventions -- Tamale Lesson: Transforming Cancer Information Through Narrative -- Es Tiempo: The Jacaranda Initiative -- Identified Gaps -- Future Research -- References -- Chapter 18: Reaching Latinos Through Social Media and SMS for Smoking Cessation -- Background -- Methods -- Program Development -- Pretesting -- Process -- Program Promotion -- Results and Discussion -- Conclusion -- References -- Chapter 19: The Need for a Holistic Approach to Prevent Reproductive Cancers Among US Latinas: The Potential Impact of Normalizing Sexuality and Improving Communication -- Introduction -- Study 1 -- Materials, Procedure, and Approach to Analysis -- Results -- Study 2 -- Materials, Procedure, and Approach to Analysis -- Results -- Discussion -- References -- Chapter 20: Critical Steps for Engaging Hispanics in Cancer Research: Building Capacity to Enhance Participation in Biospecimen Donation with Hispanic Communities -- Introduction -- Three Critical Steps for Engaging Hispanics in Cancer Research -- Step 1: Know the Community -- Step 2: Know the Goal of Engagement Activities -- Step 3: Design Activities Using Best Practice Strategies -- Discussion and Lessons Learned -- References -- Part IX: Charting the Future of Cancer Health Disparities Research in Latinos -- Chapter 21: Emerging Policies in US Health Care -- Congressman Joaquin Castro, Representative from the 20th Congressional District in Bexar County, Texas -- Dr. Esteban López, Chief Medical Officer, Clinical Strategy and Innovation at Blue Cross and Blue Shield of Texas -- Dr. Robert Croyle, Director, Division of Cancer Control and Population Sciences at the National Cancer Institute -- Dr. Elena Rios, President and CEO of the National Hispanic Medical Association -- Congressional Legislation in the 115th Congress (January 3, 2017 to January 3, 2019).

Health Policy Trends.