Dilated Cardiomyopathy : : From Genetics to Clinical Management.

• Author: Sinagra, Gianfranco.
• TeilnehmendeR: Merlo, Marco.; Pinamonti, Bruno.
• Place / Publishing House: Cham : : Springer International Publishing AG,, 2019.; ©2019.
• Year of Publication: 2019
• Edition: 1st ed.
• Language: English
• Physical Description: 1 online resource (239 pages)

Table of Contents

Intro -- Contents -- Introduction -- 1: Historical Terminology, Classifications, and Present Definition of DCM -- 1.1 Dilated Cardiomyopathies: The Classification Pathway -- 1.2 Genetic Dilated Cardiomyopathy and Etiological Classification -- 1.3 Future Perspectives -- References -- 2: Epidemiology -- 2.1 Towards Contemporary Clinical Epidemiology in Dilated Cardiomyopathy -- 2.2 Genetics and Future Perspectives -- References -- 3: Pathophysiology -- 3.1 Ventricular Remodeling in DCM -- 3.2 Genetic Pathophysiology and New Possible Proteins Involved in DCM [2] -- 3.3 Molecular Mechanisms of Cardiac Remodeling in HF [15] -- References -- 4: Etiological Definition and Diagnostic Work-Up -- 4.1 Clinical Presentation -- 4.2 Etiological Classification: A Critical Issue in Clinical Management of DCM -- 4.2.1 Need of Reclassification of the Disease During Follow-Up -- 4.3 Exclusion of Reversible Causes of Left Ventricular Dysfunction/Dilation -- 4.4 Diagnostic Work-Up in New-Onset LV Dysfunction/Dilation: A "Red Flags" Approach -- 4.4.1 Personal and Family History -- 4.4.2 Symptoms and Physical Examination -- 4.4.3 12 Lead Electrocardiogram -- 4.4.4 Laboratory Tests -- 4.4.4.1 Genetic Testing -- 4.4.5 Echocardiography -- 4.4.6 Cardiovascular Magnetic Resonance -- 4.4.7 Cardiac Catheterizations and Procedures -- 4.4.7.1 Coronary Angiogram -- 4.4.7.2 Cardiac Catheterization -- 4.4.7.3 Endomyocardial Biopsy -- 4.5 Conclusions -- References -- 5: Genetics of Dilated Cardiomyopathy: Current Knowledge and Future Perspectives -- 5.1 DCM-Associated Genes -- 5.1.1 Titin -- 5.1.2 Lamin A/C -- 5.1.3 Structural Cytoskeleton Z-Disk Genes -- 5.1.4 Desmosomal Genes -- 5.1.5 Sarcomeric (Motor) Genes -- 5.1.6 Ion Channel-Related Genes -- 5.1.7 Other Genes -- 5.2 Technical Issues in Genetic Sequencing.

5.3 The Complexity in Variant Classification Process -- 5.4 The External Modulation of Genotype: Environmental Triggers -- 5.5 Evidence-Based Genotype-Phenotype Correlations -- 5.5.1 Lamin A/C -- 5.5.2 Titin -- 5.5.3 Filamin C -- 5.5.4 Insights from Clinical Presentation and Left Ventricular Reverse Remodeling (LVRR) -- References -- 6: Clinical Presentation, Spectrum of Disease, and Natural History -- 6.1 Spectrum of Disease -- 6.2 Clinical Presentation -- 6.3 Natural History -- References -- 7: Role of Cardiac Imaging: Echocardiography -- 7.1 Echocardiographic Features of Dilated Cardiomyopathy -- 7.2 Role of New Echocardiographic Techniques -- 7.3 Clinical Echocardiography in DCM: Advantages and Limitations in Clinical Practice -- 7.4 Prognostic Role of Echocardiographic Data in DCM -- References -- 8: Role of Cardiac Imaging: Cardiac Magnetic Resonance and Cardiac Computed Tomography -- 8.1 Cardiac Magnetic Resonance -- 8.2 Diagnostic Accuracy -- 8.3 Differential Diagnosis -- 8.4 Myocarditis Presenting as Left Ventricular Dysfunction -- 8.5 Other Secondary Forms of DCM -- 8.6 Prognostic Stratification -- 8.7 Macroscopic vs. Diffuse Fibrosis -- 8.8 Strain Analysis -- 8.9 Other Prognostic Indicators -- 8.10 Computed Tomography -- References -- 9: Endomyocardial Biopsy -- 9.1 Introduction -- 9.2 Technique -- 9.3 Complications -- 9.4 Indications in DCM Scenarios -- 9.5 Diagnosis of Myocarditis -- 9.6 Examples of Endomyocardial Biopsy -- 9.6.1 Case I (J.D.) -- 9.6.2 Case II (C.P.) -- 9.6.3 Case III (C.S.) -- 9.6.4 Case IV (C.F.) -- References -- 10: Arrhythmias in Dilated Cardiomyopathy: Diagnosis and Treatment -- 10.1 Burden and Kinds of Arrhythmias in Dilated Cardiomyopathy: Risk Stratification of Sudden Death -- 10.1.1 Bradyrhythmias and Conduction Abnormalities -- 10.1.2 Supraventricular Arrhythmias.

10.1.3 Ventricular Arrhythmias -- 10.1.4 Mechanisms -- 10.1.5 Risk Stratification of Sudden Cardiac Death -- 10.1.6 Role of Supraventricular and Ventricular Arrhythmias in Pathogenesis of DCM -- 10.1.6.1 Definition and Pathophysiology -- 10.1.6.2 Specific Clinical Pictures -- 10.1.7 Management of Atrial Arrhythmias in Dilated Cardiomyopathy and Heart Failure -- 10.1.8 Management of Ventricular Arrhythmias in Dilated Cardiomyopathy -- 10.1.9 Antiarrhythmic Drug Therapy of Ventricular Arrhythmias -- 10.1.10 Catheter Ablation of Ventricular Arrhythmias -- 10.1.11 Characteristics of the Arrhythmogenic Substrate and Its Impact on Catheter Ablation Approach -- 10.1.12 Role of ICD in DCM -- References -- 11: Regenerative Medicine and Biomarkers for Dilated Cardiomyopathy -- 11.1 Strategies for Heart Regeneration -- 11.1.1 Cell Therapy -- 11.1.2 Gene Therapy -- 11.2 Regenerative Approaches in Dilated Cardiomyopathy -- 11.3 Biomarkers and Dilated Cardiomyopathy -- References -- 12: Prognostic Stratification and Importance of Follow-Up -- 12.1 Prognosis of DCM: The Milestones of the Management -- 12.2 Etiological Characterization as an Important Prognostic Factor -- 12.3 DCM as a Dynamic Disease: The Importance of Follow-Up -- 12.4 Left Ventricular Reverse Remodeling Beyond the Left Ventricle -- 12.5 Prognostic Role of Cardiopulmonary Exercise Testing -- 12.6 Arrhythmic Risk Stratification -- 12.7 The "Apparent Healing" Phenomenon -- 12.8 Uninterrupted Follow-Up and Continuous Reclassification of the Disease -- References -- 13: Current Management and Treatment -- 13.1 Familial Screening Program -- 13.2 Sport Activity Screening Program -- 13.3 Medical Treatment -- 13.4 Ventricular and Supraventricular Arrhythmias -- 13.5 Implantable Cardioverter-Defibrillator -- 13.6 Cardiac Resynchronization Therapy.

13.7 Advanced Heart Failure, Mechanical Circulatory Support, Functional Mitral Regurgitation Correction, Heart Transplantation, and Palliative Care -- References -- 14: Unresolved Issues and Future Perspectives -- 14.1 Toward a Personalized Medicine: A Genetic Approach -- 14.2 The Challenge of Arrhythmic Stratification -- 14.3 Toward Innovation in Therapy -- References -- 15: Dilated Cardiomyopathy at the Crossroad: Multidisciplinary Approach -- 15.1 Sarcoidosis: Co-working with Pneumologists -- 15.1.1 Treatment -- 15.2 Autoimmune Cardiomyopathy: Co-working with Rheumatologists -- 15.2.1 Systemic Lupus Erythematosus -- 15.2.2 Treatment -- 15.3 Infectious Disease and Cardiomyopathy: Co-working with Infectious Disease Specialist -- 15.3.1 Chagas Cardiomyopathy -- 15.3.2 Treatment -- 15.3.3 Lyme Disease -- 15.3.4 Treatment -- 15.4 Dilated Cardiomyopathy Associated with Neuromuscular Diseases: Co-working with Neurologists -- 15.5 Primary Iron-Overload Cardiomyopathy: Co-working with the Hematologists -- 15.6 Cardiomyopathy Related to Chemotherapeutic Agents: Co-working with Oncologists -- 15.6.1 Treatment -- 15.7 Alcoholic Cardiomyopathy -- 15.7.1 Treatment -- References.