Antibody-drug conjugates : : fundamentals, drug development, and clinical outcomes to target cancer / / edited by Kenneth J. Olivier Jr. and Sara A. Hurvitz.
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| Place / Publishing House: | Hoboken, New Jersey : : John Wiley & Sons, Incorporated,, [2017] 2017 |
| Year of Publication: | 2017 |
| Language: | English |
| Online Access: | |
| Physical Description: | 1 online resource (566 pages) :; color illustrations |
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Table of Contents:
- Typical antibody-drug conjugates / John Lambert
- Selecting optimal ADC targets using indication-dependent or indication-independent approaches / Robert Hollingsworth and Jay Harper
- Antibody drug conjugates : an overview of the CMC and characterization process / Janet Wolfe and Phillip Ross
- Linker and conjugation technology and improvements / Riley Ennis and Sourav Sinha
- Formulation and stability / Kouhei Tsumoto, Anthony Young, and Satoshi Ohtake
- QC assay development / Xiao-Hong Chen and Mate Tolnay
- Occupational health and safety aspects of ADCs and their toxic payloads / Robert Sussman and John Farris
- Bioanalytical strategies enabling successful ADC translation / Xiaogang Han, Lindsay King, and Steve Hansel
- Nonclinical pharmacology and mechanistic modeling of antibody drug conjugates in support of human clinical trials / Brian J. Schmidt, Chin Pan, Heather E. Vezina, Huadong Sun, Douglas D. Leipold, and Manish Gupta
- Pharmacokinetics of antibody-drug conjugates / Amrita Kamath
- Path to market approval : regulatory perspective of ADC nonclinical safety assessments / Stacey Ricci and Natalie Simpson
- Antibody drug conjugates : clinical strategies and applications / Heather E. Vezina, Lucy Lee, Brian J. Schmidt, Manish Gupta
- Antibody-drug conjugates (ADCs) in clinical development / Patricia LoRusso and Joseph McLaughlin
- ADCs approved for use : Trastuzumab emtansine (Kadcyla, T-DM1) in patients with previously treated HER2-positive metastatic breast cancer / Gail Lewis Phillips, Sanne de Hass, Sandhya Girish, and Ellie Guardino
- ADCs approved for use : Brentuximab Vedotin / Sven DeVos and Monica Mead
- Radioimmunotherapy / Jeffrey Wong and Savita Dandapani
- Radiolabeled antibody-based imaging in clinical oncology / Bart Hendriks and Daniel Gaddy
- Antibody-drug conjugates : the next evolution in the cure for cancer
- William C. Olson and Amy Q. Han.