Improving the quality of cancer clinical trials : workshop summary / / National Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs.

• Author: National Cancer Policy Forum (U.S.)
• TeilnehmendeR: Patlak, Margie.; Nass, Sharyl J.; National Cancer Policy Forum (U.S.); Institute of Medicine (U.S.); ProQuest (Firm)
• Year of Publication: 2008
• Language: English
• Physical Description: xii, 124 p. :; ill. (some col.).

Table of Contents

• Introduction
• New clinical trial designs. Phase 0 trials
• Adaptive trial designs
• Targeting multiple pathways with multiple drugs
• Preclinical model systems
• Molecular imaging. Current and developing methods
• Challenges of molecular imaging
• Screening for predictive markers. The challenges of clinical validation
• Bioimaging predictive markers
• Clinical translation
• Panel discussion
• Costs of clinical trials. Regulatory costs
• Patient accrual
• Global outsourcing
• Time is money
• Public-private collaborations
• Regulatory issues. Regulatory barriers to innovation
• Patient advocacy perspective
• Regulation of in vitro diagnostics
• Regulatory issues in improving cancer clinical trials
• Reports from the case study discussion groups. Adaptive trial design
• Phase 0 trials
• Imaging
• Use of proteomics/genomics to assign therapy in lung cancer
• Use of genetics/genomics to assign therapy.