Environment Impact on Reproductive Health : : A Translational Approach.

• Author: Marci, Roberto.
• Place / Publishing House: Cham : : Springer International Publishing AG,, 2023.; ©2023.
• Year of Publication: 2023
• Edition: 1st ed.
• Language: English
• Physical Description: 1 online resource (242 pages)

Table of Contents

Intro -- Contents -- Chapter 1: Introduction to Environmental Pollutants and Human Exposure -- 1.1 The Biological Agents -- 1.2 Radiations -- 1.3 Chemical Contaminants -- 1.3.1 Endocrine Disruptors -- 1.4 Global Warming -- References -- Chapter 2: Cellular Mechanisms of Endocrine Disruption -- 2.1 Endocrine Disruptors: Impact on Health -- 2.1.1 Effects of EDCs on Metabolism -- 2.1.2 EDCs and Cancer -- 2.1.3 Effects of EDCs on Reproduction, Growth, and Development -- 2.2 Targets of EDCs: Genomic and Nongenomic Modulation -- 2.2.1 EDCs and Genomic Modulation -- 2.2.2 EDCs and Nongenomic Modulation -- 2.3 Hormone Mimicry and Disruption by EDCs: Modulation of Hormone Activity -- 2.4 Mechanism of Action of EDCs and Estrogens -- 2.5 Mechanism of Action of EDCs and Androgens -- 2.6 Conclusions -- References -- Chapter 3: Endocrine Disruptors, Epigenetic Changes, and Transgenerational Transmission -- 3.1 Effects of Epigenetics on Human Reproduction: An Introduction -- 3.2 Association Between EDCs and Epigenetics on Human Fertility -- 3.3 Effect of EDC Epigenetics Modification on Gene Expression in Human Reproduction -- 3.4 Effect of EDC-Induced DNA Methylation on Male and Female Reproductive Tract -- 3.5 Effects of EDC-Induced DNA Methylation During Development and Germ Line Differentiation -- 3.6 Final Considerations -- References -- Chapter 4: Introduction to Environmental Pollutants and Human Reproduction -- 4.1 Introduction -- 4.1.1 Recent Trends in Human Reproduction -- 4.1.2 Environmental Pollutants -- 4.1.2.1 Air Pollution -- 4.1.2.2 Polycyclic Aromatic Hydrocarbons -- 4.1.2.3 Pesticides -- 4.1.2.4 Parabens -- 4.1.2.5 Perfluorooctanesulfonate (PFOS)/Perfluorooctanoate (PFOA) -- 4.1.3 A Striking Example: The Role of Bisphenol -- 4.1.3.1 Bisphenol Pathophysiological Impact -- 4.1.3.2 Bisphenol A and Infertility.

The Reproductive Organ Impairment in Females -- The Folliculogenesis Impairment -- The Altered Embryo Implantation -- 4.1.3.3 To Strengthen the Concept: The Role of Phthalates -- References -- Chapter 5: Endocrine Disruption in Women: A Cause of PCOS, Early Puberty, or Endometriosis -- 5.1 Introduction -- 5.2 PCOS -- 5.3 Early Puberty and EDCs -- 5.4 Phthalates -- 5.5 BPA (Bisphenol A) -- 5.6 Pesticides -- 5.7 Endometriosis -- 5.8 Bisphenols -- 5.9 Dioxins and Dioxin-Like Compounds -- 5.10 Phthalates -- 5.11 Medications as Endocrine Disruptors -- 5.11.1 Diethylstilbestrol -- 5.12 Conclusion -- References -- Chapter 6: Endocrine Disruptors and Cancers in Women -- 6.1 Introduction -- 6.2 The Importance of Studying Endocrine Disruptors When Studying the Genesis of Breast Cancer -- 6.3 Endocrine Disruptors and Breast Cancer -- 6.3.1 Organochlorines (DDT, dichlorodiphenyldichloroethylene [DDE], and PCB) -- 6.3.1.1 In Vitro Studies and Organochlorines -- 6.3.1.2 In Vivo Studies and Serum Organochlorine Levels -- 6.3.1.3 In Vivo Studies and Fat Levels of Organochlorines -- 6.3.2 Bisphenol A and Phthalates -- 6.4 Endocrine Disruptors and Endometrial/Ovarian Cancer -- 6.5 Conclusion -- References -- Chapter 7: Endocrine Disruption in the Male -- 7.1 Introduction -- 7.2 Mechanism of Action of EDCs on Hypothalamic-Pituitary-Gonadal Axis -- 7.3 Bisphenol A -- 7.4 Phthalates -- 7.5 Perfluoroalkyl Compounds -- 7.6 Conclusions -- References -- Chapter 8: Endocrine-Disrupting Chemicals (EDCs) and Reproductive Outcomes -- 8.1 Introduction -- 8.2 Impact of EDCs on IVF Outcomes -- 8.2.1 Bisphenol A -- 8.2.2 Phthalates -- 8.2.3 Triclosan -- 8.2.4 Parabens -- 8.2.5 Persistent Organic Pollutants -- 8.2.6 Implications for Practice -- 8.3 Impact of EDCs on Pregnancy Outcomes -- 8.3.1 Miscarriage -- 8.3.2 Preeclampsia -- 8.3.3 Infant Birth Weight -- 8.3.4 Cholestasis.

8.4 Conclusion -- References -- Chapter 9: Endocrine-Disrupting Chemicals and the Offsprings: Prenatal Exposure -- 9.1 Introduction -- 9.2 Identification Overview -- 9.2.1 Endocrine Glands and System -- 9.2.1.1 Glands -- 9.2.1.2 Hormones -- 9.2.1.3 Receptors -- 9.2.2 Reproductive Health -- 9.2.3 Environment -- 9.2.4 Endocrine Disruptor Chemicals -- 9.2.4.1 Endocrine Disruptor Chemicals and Action Overview -- 9.2.4.2 Endocrine Disruptor Chemical Effects on Human Body Systems, Reproductive Health, Prenatal Exposure, and Offsprings -- 9.2.4.3 EDCs' Effects on Female and Male Reproductive Health -- 9.3 States of EDC Science -- References -- Chapter 10: Policy Implication and Community Interventions to Reduce EDCs Exposure -- 10.1 Introduction -- 10.2 Europe Police Priorities on EDCs: REACH Regulation, European Plant Protection Products Regulation (PPPR), Biocidal Products Regulation (BPR) -- 10.3 Other EDCs Regulations -- 10.4 Economic Burden -- 10.5 Limiting Exposure to EDCs -- 10.6 Policy Management and Recommendations -- 10.7 Conclusion -- References -- Chapter 11: Talking with Patients and the Public About Endocrine-Disrupting Chemicals -- 11.1 Scope of the Problem -- 11.2 Empowering Healthcare Professionals to Talk with Patients and the Public About EDCs -- 11.3 Taking An Environmental Exposure History -- 11.4 Patient (and Clinician) Resources -- 11.5 Resources for Healthcare Professionals, Trainees, and Others -- 11.6 Talking with Patients and the Public About EDCs and Risk Assessment and Mitigation -- 11.7 How Healthcare Providers Can Advocate for Change -- 11.8 What Will It Take for People to Pay Attention to EDCs and Human Health? -- 11.9 Summary -- References.