Juan Carlos De la Concepcion

Current project:

Evolution of plant exocytosis

I investigate the plant exocyst complex as a model to understand how macromolecular complexes evolve and acquire new functions. For this, I use a multidisciplinary approach that includes proteomics, electron cryomicroscopy, and comparative biology.

Publications:

De la Concepcion JC, Vega Benjumea J, Bialas A, Terauchi R, Kamoun S, Banfield MJ. Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair. Elife. 2021 Nov 16;10:e71662. doi: 10.7554/eLife.71662. PMID: 34783652; PMCID: PMC8631799.
De la Concepcion JC, Maidment JHR, Longya A, Xiao G, Franceschetti M, Banfield MJ. The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface. PLoS Pathog. 2021 Mar 1;17(3):e1009368. doi: 10.1371/journal.ppat.1009368. PMID: 33647072; PMCID: PMC7951977.
De la Concepcion JC, Franceschetti M, MacLean D, Terauchi R, Kamoun S, Banfield MJ. Protein engineering expands the effector recognition profile of a rice NLR immune receptor. Elife. 2019 Sep 19;8:e47713. doi: 10.7554/eLife.47713. PMID: 31535976; PMCID: PMC6768660.
De la Concepcion JC, Franceschetti M, Maqbool A, Saitoh H, Terauchi R, Kamoun S, Banfield MJ. Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen. Nat Plants. 2018 Aug;4(8):576-585. doi: 10.1038/s41477-018-0194-x. Epub 2018 Jul 9. Erratum in: Nat Plants. 2018 Sep;4(9):734. PMID: 29988155.

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Juan Carlos De la Concepcion

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Vienna BioCenter