Contact
Email: jian.kok(at)gmi.oeaw.ac.at
Telephone: +43 1 79044/9815
https://orcid.org/0000-0002-9959-7542
FORMER AND CURRENT POSITIONS
since 2021 - PhD candidate in the Berger Group
2020 - Master of Science in Cancer Cell and Molecular Biology at the University of Leicester, United Kingdom
2019 - Bachelor of Arts (Hons) at the University of Cambridge, United Kingdom
Research Projects
Characterizing The Role Of SNF2-ATPase Nucleosome Remodellers In Fission Yeast
Since chromatin frequently needs to be restructured, a class of molecular motors – the Snf2-ATPase remodellers – have evolved in all eukaryotes to slide, evict and incorporate nucleosomes, which then results in an altered chromatin landscape. Currently, only limited information is available on the mechanisms and relationships between the different Snf2 ATPases, thus I am currently trying to shed insight into the functions and cellular pathways these remodeler proteins are involved in using fission yeast as a model organism.
Understanding The Interplay Between The CHD1 Nucleosome Remodeller and Transcription
CHD1 is known to facilitate the incorporation and repositioning of nucleosomes, thereby influencing the accessibility of DNA to the transcriptional machinery. This project aims to investigate how CHD1 influences transcriptional dynamics, chromatin structure, and gene expression, contributing to a comprehensive understanding of its function in gene regulation.
Research interests
Eukaryotes have managed to solve the problem of nuclear genome compaction by folding their genome into chromatin, which is a highly dynamic structure that serves to both impart structural organization and facilitate several key processes such as gene expression, DNA replication, and repair. My main interest lies in the functional mechanisms and pathways governing how chromatin is remodelled and restructured according to specific cellular needs. In addition, I am also interested in how cells utilize different systems including histone variants along with their various post-translational modifications in order to regulate gene expression and transcription.