Building better brains

Scientists from OeAW combined organoids with bioengineering. Using small microfilaments, they show improved tissue architecture that mimics human brain development more accurately and allows more targeted studies of brain development and its malfunctions, as reported in the current issue of “Nature Biotechnology”.

Biotechnologisch weiterentwickelte Organoide, sogenannte enCORs, wachsen im Nährmedium entlang einer Struktur winziger Kunststoff-Fasern und sind dem Original in Form und Struktur noch ähnlicher. © IMBA

Bioengineered organoids or so called enCORs are supported by a floating scaffold of PLGA-fiber microfilaments. © IMBA

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Unique genome architectures after fertilisation in single-cell embryos